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Curvature-Regularized Robust Medical Image Classification

Novel deep learning framework combining CURE loss, depthwise separable & dilated convolutions, and attention mechanisms — achieving only 5.6% accuracy drop under adversarial attacks.

Problem

Medical image classification models are vulnerable to adversarial perturbations, raising safety concerns in clinical deployment. Standard training fails to produce robust models under input noise.

Action

Developed MedMamba framework applying curvature regularization (CURE) to control Hessian eigenvalues for enhanced robustness. Designed a dual-branch SS-Convd-SSM module combining dilated and depthwise separable convolutions with attention for precise feature extraction. Validated robustness through FGSM and PGD adversarial attacks.

Result

Under adversarial attack, the model showed only a 5.6% drop in average accuracy and 4.1% drop in AUC — demonstrating strong robustness compared to baseline methods. Published at ICCGIV 2024.

Learnings

Gained expertise in adversarial robustness, curvature regularization theory, and designing neural architectures that balance efficiency with resilience to input perturbations.

Tech Stack

PyTorch
CURE Loss
FGSM
PGD
Depthwise Separable Conv
Dilated Conv
Attention
Python